Concurrent Validation and Statistical Analysis of Novel Bi-Layer Floating Tablet of Sucralfate and Metoprolol Succinate

Abstract

The research work is based on validation and statistical analysis of Bilayer Floating Tablet containing bilayer floating tablet of Sucralfate and Metoprolol Succinate. First the initially formulated and evaluated Bi layer floating tablet of Sucralfate and Metoprolol succinate (DSFMS). We performed the stability study as per the ICH guideline. Then evaluation of the tablets according to Concurrent validation process. Then final resultant value compared with the initial resultant values and checked the equivalency with the acceptance criteria of Bilayer Floating Tablet. Then statistical analysis were done by calculating mean deviation and standard aviation. Then compared statistical parameters a over limit or under limit.
After stability study and Concurrent validation of (DSFMS) it is confirmed that the formulation fulfill all the acceptance criteria of Bilayer floating tablet. It is confirmed that the formulation (DSFMS) satisfying all acceptance criteria of Bilayer floating tablet. The statistical parameters are under limit.