International Journal of Research and Scientific Innovation (IJRSI)
Genotypic and Phenotypic Detection of Multidrug-Resistant Mycobacterium Tuberculosis among HIV Patients Attending Tuberculosis Reference Centres in Northwest, Nigeria
Published January 24, 2026 • Vol. 13, Issue 15, pp. 1363–1371Open Access
DOI: 10.51244/IJRSI.2026.1315PH00019
Abstract
In light of the escalating issue of tuberculosis resistance, it is imperative to consistently evaluate and examine therapeutic strategies. This study focus on genotypic and phenotypic detection of multidrug-resistant Mycobacterium tuberculosis among HIV patients attending tuberculosis reference centres in Northwest, Nigeria. A total of 503 sputum samples were collected aseptically among three referral facilities in Northwest using random sampling method. Molecular drug susceptibility testing was performed using Geno Type® MTBD Rplus assay. The overall prevalence was 4.3 %. The highest prevalence in relation to state was observed from Katsina (22.2 %) and the lowest was from Sokoto (3.6 %). The highest prevalence was observed among male patients (4.8%) while the female patients (3.4%). Age 66-70 yrs recorded the highest prevalence (100 %) and the lowest was 36-40 yrs and 41-45yrs (4.4 %). The highest resistance patterns were isolates from Kebbi were resistance to INH+ RIF+ FLQ (50.0 %) and the lowest was from Kaduna INH+ AMG (20.0 %). Routine TB testing among HIV patients must be improved to guide co-management
Keywords: Multidrug-resistant, Mycobacterium tuberculosis, HIV patents
| Journal | International Journal of Research and Scientific Innovation (IJRSI) |
|---|---|
| ISSN | 2321-2705 |
| Volume / Issue | Volume 13, Issue 15 |
| Pages | 1363–1371 |
| Publication date | January 24, 2026 |
| DOI | 10.51244/IJRSI.2026.1315PH00019 |
| Publisher | RSIS International |
| License | Open Access |
How to cite this article
Tubi, A. O., Gyar S. D., & Ngwai Y. B (2026). Genotypic and Phenotypic Detection of Multidrug-Resistant Mycobacterium Tuberculosis among HIV Patients Attending Tuberculosis Reference Centres in Northwest, Nigeria. International Journal of Research and Scientific Innovation (IJRSI), 13(15), 1363-1371. https://doi.org/10.51244/IJRSI.2026.1315PH00019
BibTeX
@article{Tubi2026,
title = {Genotypic and Phenotypic Detection of Multidrug-Resistant Mycobacterium Tuberculosis among HIV Patients Attending Tuberculosis Reference Centres in Northwest, Nigeria},
author = {Tubi, A. O. and Gyar S. D. and Ngwai Y. B},
journal = {International Journal of Research and Scientific Innovation (IJRSI)},
volume = {13},
number = {15},
pages = {1363--1371},
year = {2026},
doi = {10.51244/IJRSI.2026.1315PH00019},
publisher = {RSIS International}
}