International Journal of Research and Scientific Innovation (IJRSI)
Evaluation of Inflammatory Biomarker IL-8 in Helicobacter Pylori-Associated Gastritis
Published May 15, 2026 • Vol. 13, Issue 15, pp. 2400–2406Open Access
DOI: 10.51244/IJRSI.2026.1315PH00088
Abstract
Helicobacter pylori gastritis has been recognized as a significant risk factor for the development of gastric cancer. This study aimed to evaluate the role of interleukin-8 (IL-8) in Helicobacter pylori-Associated Gastritis disease progression. A total of 65 participants in the present study 35(58%)with symptoms of gastritis, were diagnosed and included in the study, along with 25 healthy controls. Gastric biopsy samples (mucus layer) were collected, and IL-8 concentrations were measured using an ELISA assay (Solarbio Human IL-8 ELISA Kit). Absorbance was recorded using a Fisher Scientific ELISA plate reader. Patients with gastritis who tested positive for Helicobacter pylori by PCR analysis—using glmM-specific primers—showed significantly elevated levels of IL-8 compared to healthy controls (17.78 pg/mL vs. 9.05 pg/mL, p < 0.001). These findings demonstrate a marked increase in IL-8 levels in patients with H. pylori-induced gastritis, underscoring its critical role in mediating inflammatory responses and contributing to disease pathogenesis.
Keywords: IL-8, glmM, PCR,Helicobacter. pylori, ureC
| Journal | International Journal of Research and Scientific Innovation (IJRSI) |
|---|---|
| ISSN | 2321-2705 |
| Volume / Issue | Volume 13, Issue 15 |
| Pages | 2400–2406 |
| Publication date | May 15, 2026 |
| DOI | 10.51244/IJRSI.2026.1315PH00088 |
| Publisher | RSIS International |
| License | Open Access |
How to cite this article
Mohammed Ejresh, & Alya A. Rahi (2026). Evaluation of Inflammatory Biomarker IL-8 in Helicobacter Pylori-Associated Gastritis. International Journal of Research and Scientific Innovation (IJRSI), 13(15), 2400-2406. https://doi.org/10.51244/IJRSI.2026.1315PH00088
BibTeX
@article{Mohammed2026,
title = {Evaluation of Inflammatory Biomarker IL-8 in Helicobacter Pylori-Associated Gastritis},
author = {Mohammed Ejresh and Alya A. Rahi},
journal = {International Journal of Research and Scientific Innovation (IJRSI)},
volume = {13},
number = {15},
pages = {2400--2406},
year = {2026},
doi = {10.51244/IJRSI.2026.1315PH00088},
publisher = {RSIS International}
}