Phytochemical Profiling and Evaluation of Antioxidant, Antidiabetic Potential of Aegle Marmelos Leaves

Abstract

Medicinal plants are an important source of natural bioactive compounds with significant therapeutic potential. Aegle marmelos is a well-known medicinal plant widely used in traditional systems of medicine for the treatment of various ailments, including diabetes and oxidative stress-related disorders. The present study was undertaken to evaluate the phytochemical constituents and biological activities of Aegle marmelos leaf extract.
Preliminary phytochemical screening was carried out using standard qualitative methods, which revealed the presence of important secondary metabolites such as flavonoids, glycosides and steroids. The total phenolic and total flavonoid contents of the extract were also determined, indicating the presence of polyphenolic compounds.
The antioxidant activity of the extract was evaluated using the DPPH free radical scavenging assay, while the antidiabetic potential was assessed through the α-amylase inhibition assay. The results demonstrated that the extract exhibits notable antioxidant and antidiabetic activities.
Further analysis using HPTLC confirmed the presence of flavonoid compounds, while LC–MS profiling revealed a diverse range of phytoconstituents, indicating the chemical complexity of the extract.
Overall, the findings suggest that Aegle marmelos leaves are a promising source of bioactive compounds with potential therapeutic applications, supporting their traditional medicinal use.