Effects of Soya Bean (Glycine Max) Extract on the Histology of Livers of Sniper Induced Rats

Abstract

Objective: This research was carried out to investigate the effect of Soya bean (Glycine max) extract on the histology of livers of sniper-induced rats.
Methodology: Twenty-five rats weighing 110 g to 150 g were procured and acclimatized for two weeks, thereafter; they were divided into five groups of five rats each, and were housed in cages. The groups were designated as groups A - E. Group A served as the control group and was not induced, while groups B – E were induced. Group A and B received distilled water only, while groups C – E received Vitamin C, 200 mg/kg of body weight and 400 mg/kg of body weight of extracts of Soya bean respectively for 21 days orally through oro-gastric tube. On the 22nd day, the animals were weighed, sacrificed via chloroform inhalation, and livers were harvested for histological study.
Results: Histopathological findings showed normal hepatic architecture with with central vain (CV) and active hepatocyte (H) in group A, severe degeneration with severe aggregate intra-hepatic inflammation (IHI) in group B, moderate healing with mild aggregate intra-hepatic inflammation (IHI) with active hepatocyte (H) in group C, mild healing with moderate aggregate intra-hepatic inflammation (IHI) with active hepatocyte (H) in group D, and moderate healing with mild aggregate intra-hepatic inflammation (IHI) in group E.
Conclusion: The extract of Soya bean has ameliorating effect on the histology of livers of sniper-induced rats, and the ameliorating effect improves with increase in the dosages of the extract