Comparative Effectiveness of Desensitizing Agents for the Management of Dentin Hypersensitivity: A Systematic Review

Abstract

Dentin hypersensitivity (DH) is a common clinical condition characterized by short, sharp pain arising from exposed dentin in response to thermal, tactile, osmotic, or chemical stimuli. Numerous desensitizing agents have been introduced to manage this condition, yet their comparative effectiveness remains unclear. This systematic review evaluates the clinical performance and mechanisms of action of commonly used desensitizing agents, including potassium nitrate, stannous fluoride, arginine calcium carbonate, nano hydroxyapatite, resin based sealants, and laser therapy.