International Journal of Research and Scientific Innovation (IJRSI)
A Comprehensive Review of Analytical Method Development and Validation for Imeglimin Hydrochloride.
Published April 30, 2026 • Vol. 13, Issue 4, pp. 634–637Open Access
DOI: 10.51244/IJRSI.2026.1304000063
Abstract
Imeglimin Hydrochloride is a novel oral antidiabetic agent used in the management of type 2 diabetes mellitus, characterized by its unique mechanism of action targeting mitochondrial bioenergetics. The increasing therapeutic significance of Imeglimin necessitates the development of robust, accurate, and reliable analytical methods for its identification, quantification, and quality control in bulk and pharmaceutical dosage forms. This comprehensive review focuses on the various analytical techniques developed for the estimation of Imeglimin Hydrochloride, including spectroscopic methods such as UV–Visible spectrophotometry and advanced chromatographic techniques like High-Performance Liquid Chromatography (HPLC), High Performance Thin Layer Chromatography (HPTLC), and Liquid Chromatography–Mass Spectrometry (LC– MS). Emphasis is placed on method development strategies, including selection of solvents, mobile phase optimization, detection wavelength, and column characteristics to achieve optimal sensitivity and specificity.
Keywords: Analytical methods, Type 2 diabetes, Glimins (mitochondrial modulators), Antidiabetic, Imeglimin hydrochloride.
| Journal | International Journal of Research and Scientific Innovation (IJRSI) |
|---|---|
| ISSN | 2321-2705 |
| Volume / Issue | Volume 13, Issue 4 |
| Pages | 634–637 |
| Publication date | April 30, 2026 |
| DOI | 10.51244/IJRSI.2026.1304000063 |
| Publisher | RSIS International |
| License | Open Access |
How to cite this article
Punase Vaishnavi, Dr. Uday A. Deokate, Muskan Mulla, Lalit Bhoye, Sapate Ruturaj, & Mujawar Alphiya (2026). A Comprehensive Review of Analytical Method Development and Validation for Imeglimin Hydrochloride.. International Journal of Research and Scientific Innovation (IJRSI), 13(4), 634-637. https://doi.org/10.51244/IJRSI.2026.1304000063
BibTeX
@article{Punase2026,
title = {A Comprehensive Review of Analytical Method Development and Validation for Imeglimin Hydrochloride.},
author = {Punase Vaishnavi and Dr. Uday A. Deokate and Muskan Mulla and Lalit Bhoye and Sapate Ruturaj and Mujawar Alphiya},
journal = {International Journal of Research and Scientific Innovation (IJRSI)},
volume = {13},
number = {4},
pages = {634--637},
year = {2026},
doi = {10.51244/IJRSI.2026.1304000063},
publisher = {RSIS International}
}