“From Gut to Gonads: A Rare Journey of Jejunal Neuroendocrine Tumor to the Testis”

Abstract

Neuroendocrine tumors (NETs) are uncommon epithelial neoplasms originating from neuroendocrine cells, within the gastrointestinal tract—particularly the jejunum and ileum, being the most frequent primary sites. While NETs account for approximately 0.5% of all malignancies, metastatic spread occurs in about 30% of cases, most commonly to the liver. Testicular metastasis from NETs is extremely rare, representing less than 1% of testicular tumors. We report a rare case of 65-year-old male who presented with a painless right scrotal swelling. Imaging revealed a well-defined hypervascular testicular mass and a similar lesion in the midjejunum with mesenteric involvement. The patient underwent segmental jejunal resection and right high inguinal orchidectomy. Histopathology and immunohistochemistry confirmed the diagnosis of a welldifferentiated - Grade I -jejunal NET with testicular metastasis.