Effect of Phenanthrene Exposure on the Total Antioxidant Capacity, Catalase, Superoxide Dismutase and Xanthine Oxidase, of the Liver.

Abstract

Phenanthrene, an aromatic compound, represents the majority of polycyclic aromatic hydrocarbons found in the environment. Sources include, burnt smoky coal particles, soil and sediment, diesel emissions, tobacco and food smoke. The aim of the study was to determine the effect of phenanthrene on oxidative stress markers in male wistar rats. Fifty healthy rats weighing between 100 and 180g were used for this study. They were administered phenanthrene via oral gavage at 5mg and 10mg over 21days, 180mg and 900mg once. Results of the experiment showed significant increase in Superoxide dismutase, Xanthine oxidase levels and in Total antioxidant capacity. Phenanthrene increased oxidative stress, in male wistar rats.