International Journal of Research and Scientific Innovation (IJRSI)
Advances on Quinoline Derivatives: A Review of Synthesis and Biological Activities
Published September 25, 2025 • Vol. 12, Issue 9, pp. 2584–2610Open Access
DOI: 10.51244/IJRSI.2025.120800228
Abstract
Quinoline compounds and their derivatives have a vast distribution in nature coupled with their immense therapeutic potential. Due to the unfading therapeutic benefits of these compounds over the years, a lot of researchers are exploring the synthesis of various derivatives of quinoline which are screened for different therapeutic activities including, anti-malarial, anti-microbial, anti-inflammatory, anti-convulsant, anti-cancer anti-mycobacterial, cardio-protective, neuroprotective activity etc. This review highlights various advances in the synthetic routes and methodology for some quinoline derivatives including Friedlander modified metal-catalyzed reactions, Photo-induced oxidative annulation reaction, Microwave-assisted doebner reaction and their biological properties.
Keywords: Quinolines, Derivatives, Synthetic routes, biological properties
| Journal | International Journal of Research and Scientific Innovation (IJRSI) |
|---|---|
| ISSN | 2321-2705 |
| Volume / Issue | Volume 12, Issue 9 |
| Pages | 2584–2610 |
| Publication date | September 25, 2025 |
| DOI | 10.51244/IJRSI.2025.120800228 |
| Publisher | RSIS International |
| License | Open Access |
How to cite this article
Emmanuel Chinedu Nnadi, Vivian Ifeoma Okonkwo, Chidinma Eucharia Ikwelle, Faith Temitope Elijah, Anulika Ruphina Phil-Mba, Vivian Chinenye Odo, & Blessing Ginika Eke (2025). Advances on Quinoline Derivatives: A Review of Synthesis and Biological Activities. International Journal of Research and Scientific Innovation (IJRSI), 12(9), 2584-2610. https://doi.org/10.51244/IJRSI.2025.120800228
BibTeX
@article{Emmanuel2025,
title = {Advances on Quinoline Derivatives: A Review of Synthesis and Biological Activities},
author = {Emmanuel Chinedu Nnadi and Vivian Ifeoma Okonkwo and Chidinma Eucharia Ikwelle and Faith Temitope Elijah and Anulika Ruphina Phil-Mba and Vivian Chinenye Odo and Blessing Ginika Eke},
journal = {International Journal of Research and Scientific Innovation (IJRSI)},
volume = {12},
number = {9},
pages = {2584--2610},
year = {2025},
doi = {10.51244/IJRSI.2025.120800228},
publisher = {RSIS International}
}