Quantitative Assessment of Serum C - Reactive Protein Levels among Smokers and Non Smokers

Abstract

Background: Recent progress in the comprehension of intricate tumor interactions has resulted in the identification of a link between inflammation and cancer. A high level of pro-inflammatory cytokines within the tumor microenvironment can stimulate angiogenesis, thereby promoting neoplastic proliferation. Serum C-reactive protein serves as a sensitive indicator of inflammation and could possess considerable prognostic significance as an early biomarker for cancer diagnosis. Aims and Objectives: To quantitatively measure serum C-reactive protein levels in both smokers and non-smokers, as well as to assess its role in cancer development. Materials and Methods: The study included a sample of 25 non-smokers and 25 smokers. All samples underwent C-reactive protein testing using immunoturbidimetry. The observations were analyzed statistically. Statistical analysis: The data was entered into the database management system of SPSS version 20.0. An independent t-test and Mann-Whitney U test were utilized to compare the C-reactive protein levels between two groups. For pairwise comparisons, Tukey's multiple post hoc procedure was employed. Results: The average C-reactive protein level in non-smokers was 55.24±12.0312, while in smokers, it was 55.88±11.76. In smokers, the C-reactive protein level was slightly higher compared to non-smokers. The comparison between non-smokers and smokers regarding C-reactive protein values showed statistical significance, with a p-value of ≤0.05. Conclusion: Our results indicate that the concentration of serum C-reactive protein was higher in smokers and is linked to an increased risk of developing oral cancer, potentially serving as a biomarker.