International Journal of Research and Scientific Innovation (IJRSI)
Determination of pKa Value for Ranolazine and Atenolol Using UV Spectroscopy
Published August 28, 2025 • Vol. 12, Issue 8, pp. 166–170Open Access
DOI: 10.51244/IJRSI.2025.120800015
Abstract
To develop innovative drug delivery methods the knowledge of a drug's physicochemical properties, namely its ionization constants is essential. Ranolazine and Atenolol are two key drugs used in clinical practice to treat cardiac arrest and their pKa values are important in developing new formulations these drugs. In the present study pKa values were measured experimentally using UV-spectrophotometry, which is known for providing accurate and reproducible pKa values. In pharmaceutical research, the ionization constant (pKa) is an important physicochemical parameter since it determines the dissolving capacity of active substances and to decide the route of administration. The study found that the pKa values for Ranolazine and Atenolol were approximately 7.6 and 9.3, respectively.
Keywords: UV-spectrophotometry, Ranolazine, Atenolol, pKa value etc
| Journal | International Journal of Research and Scientific Innovation (IJRSI) |
|---|---|
| ISSN | 2321-2705 |
| Volume / Issue | Volume 12, Issue 8 |
| Pages | 166–170 |
| Publication date | August 28, 2025 |
| DOI | 10.51244/IJRSI.2025.120800015 |
| Publisher | RSIS International |
| License | Open Access |
How to cite this article
H. D. Bandhavya, & K. C. Chaluvaraju (2025). Determination of pKa Value for Ranolazine and Atenolol Using UV Spectroscopy. International Journal of Research and Scientific Innovation (IJRSI), 12(8), 166-170. https://doi.org/10.51244/IJRSI.2025.120800015
BibTeX
@article{H2025,
title = {Determination of pKa Value for Ranolazine and Atenolol Using UV Spectroscopy},
author = {H. D. Bandhavya and K. C. Chaluvaraju},
journal = {International Journal of Research and Scientific Innovation (IJRSI)},
volume = {12},
number = {8},
pages = {166--170},
year = {2025},
doi = {10.51244/IJRSI.2025.120800015},
publisher = {RSIS International}
}