Integrative Ayurvedic and Biomedical Management of Polycystic Ovary Syndrome: A Longitudinal N-of-1 Observational Study with Clinical and Reproductive Outcomes

Abstract

background: Polycystic Ovary Syndrome (PCOS) is a chronic endocrine–metabolic disorder marked by hyperandrogenism, anovulation, and insulin resistance. Integrative approaches combining classical Ayurveda with modern biomedical therapy are frequently used in India, yet systematically documented real-world outcomes remain scarce.

Objective: To document longitudinal menstrual, metabolic, and reproductive outcomes in a woman with PCOS following an integrative Ayurvedic–biomedical therapeutic regimen.

Methods: An N-of-1, eight-month prospective observational study was conducted on a 25-year-old woman with ultrasound-confirmed PCOS. Therapy included metformin and myo-inositol along with classical Ayurvedic formulations targeting Kapha–Vata Dushti, Agnimandya, and Srotorodha. Outcomes included menstrual cyclicity, ultrasound-based ovulation tracking, serial haemoglobin trends, symptomatic changes, and conception status. All biomedical safety parameters (LFT, KFT) were monitored.

Results: Menstrual cycles gradually normalized (from >45 days to 28–32 days). Ovulation was confirmed by follicular ultrasound. Haemoglobin increased from 7.3 g/dL to 10.2 g/dL over the observation period. A spontaneous conception occurred in January 2025. Safety parameters remained within normal limits. Causality cannot be inferred due to concurrent biomedical therapy and absence of hormonal markers.

Conclusion: Integrative care in this single-subject study was associated with improved cycle regularity, ovulatory function, hematological restoration, and conception. Controlled trials with standardized protocols are required to evaluate efficacy and mechanisms.