Development and Evaluation Valsartan Containing Controlled Release Pellets

Abstract

The concept of controlled drug delivery has been explored for the delivery of drugs for prolong period of time for the past few years. This type of drug delivery has proved to provide a solution to several problems encountered in the repeated administration of such drugs. Utilizing the concept of incorporating drug in to the polymer matrices and extend the drug release for prolong period of time. The present study is an attempt to formulate and evaluate sustained release pellets of valsartan, in view to improve patient compliance and therapeutic action. To increase therapeutic efficacy, reduce frequency of administration and for better patient compliance once daily sustained release valsartan pellets proposed for extended-release dosage forms as it offers several manufacturing and biopharmaceutical advantages. The spherical shape and low surface area to volume ratio of pellets are advantageous for uniform film coating. Ethylcellulose in combination with Eudragit NE 30D was employed in this research to sustain the drug release for 24 hours by using layering technology. Here, Ethylcellulose acts as a release retarding polymer and Eudragit NE 30D acts as a film forming agent.