Synthesis and Characterization of Antibacterial Agents: Spectroscopic Insights and Biological activity Evaluation
by Gopala Krishna Murthy H.R
Published: March 17, 2026 • DOI: 10.51584/IJRIAS.2026.110200111
Abstract
Antibacterial resistance continues to threaten public health worldwide, prompting the development of novel small-molecule antibacterial agents. Herein, we report the synthesis, spectroscopic characterization, and antibacterial activity assessment of a series of novel heterocyclic derivatives. Structural confirmation was achieved through FT-IR, 1H / 13C NMR, and mass spectrometry. Antibacterial efficacy was evaluated against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) strains. The synthesized compounds exhibited comparable or superior efficacy relative to standard antibiotics, supporting their potential as future therapeutic agents.