International Journal of Research and Innovation in Applied Science (IJRIAS)
Comparative Molecular Docking of Hyptis Verticillata Phytocompounds Against DNA Gyrase B and Multiple Bacterial Drug Targets
Published December 27, 2025 • Vol. 10, Issue 11, pp. 1648–1656Open Access
DOI: 10.51584/IJRIAS.2025.101100153
Abstract
The rise of antimicrobial resistance (AMR) has become one of the most critical global health challenges, with multidrug-resistant bacteria severely reducing the efficacy of conventional antibiotics. According to the World Health Organization, resistant strains of Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli pose significant therapeutic challenges due to multiple resistance mechanisms, including efflux pump activation, enzymatic degradation, and mutation of drug targets (WHO, 2020). These limitations highlight the urgent need for alternative therapeutic strategies and novel bioactive scaffolds.
Keywords: Hyptis verticillata; molecular docking; follicle-stimulating hormone receptor
| Journal | International Journal of Research and Innovation in Applied Science (IJRIAS) |
|---|---|
| ISSN | 2454-6194 |
| Volume / Issue | Volume 10, Issue 11 |
| Pages | 1648–1656 |
| Publication date | December 27, 2025 |
| DOI | 10.51584/IJRIAS.2025.101100153 |
| Publisher | RSIS International |
| License | Open Access |
How to cite this article
Eze, Kingsley Chijioke, Dearsly, Emmanuel Markus, Oshatuyi Olukayode, Ofutet, Emmanuel Oleba, Imasa, Friday Okeje, Akwagiobe, Emmanuel Ushigianle, Ekwu Marvis Titi, Agada Victoria Anyenu, & Umoh Ukeme Etop (2025). Comparative Molecular Docking of Hyptis Verticillata Phytocompounds Against DNA Gyrase B and Multiple Bacterial Drug Targets. International Journal of Research and Innovation in Applied Science (IJRIAS), 10(11), 1648-1656. https://doi.org/10.51584/IJRIAS.2025.101100153
BibTeX
@article{Eze2025,
title = {Comparative Molecular Docking of Hyptis Verticillata Phytocompounds Against DNA Gyrase B and Multiple Bacterial Drug Targets},
author = {Eze, Kingsley Chijioke and Dearsly, Emmanuel Markus and Oshatuyi Olukayode and Ofutet, Emmanuel Oleba and Imasa, Friday Okeje and Akwagiobe, Emmanuel Ushigianle and Ekwu Marvis Titi and Agada Victoria Anyenu and Umoh Ukeme Etop},
journal = {International Journal of Research and Innovation in Applied Science (IJRIAS)},
volume = {10},
number = {11},
pages = {1648--1656},
year = {2025},
doi = {10.51584/IJRIAS.2025.101100153},
publisher = {RSIS International}
}